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Tramadol another use includes using it for relieving pain from back pain, sciatica, and for postoperative pain following spine surgery. For most adults, the maximum safe dose is 400 mg per day of immediate-release tablets. It has been proved that tramadol hydrochloride can allow a significant reduction in the dose of NSAID without compromising the relief of pain.

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Everyone naturally has endogenous opioids inside their body, which can bind to special receptors, called opioid receptors, to activate several effects in the body. When an endogenous opioid attaches to the right receptor, it can lead to several effects in the body including:
* Analgesia to relieve pain;
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Tramadol manipulates this natural process by activating the same receptors that the endogenous opioids do, in particular the mu opioid receptors. It mimics the effect of natural opioids in your body to provide pain relief.

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