CariDotMy

 Forgot password?
 Register

ADVERTISEMENT

View: 1772|Reply: 1

Sharks show novel evolution of immune, cancer-related genes

[Copy link]
Post time 31-1-2017 06:02 AM | Show all posts |Read mode
Jan. 30, 2017
Sharks show novel evolution of immune, cancer-related genes
Michael Scholl/Provided


Hammerhead Shark
A new study of shark DNA, including from great white and great hammerhead sharks, reveals unique modifications in their immunity genes that may underlie their rapid wound healing and possibly higher resistance to cancers.

This finding brings researchers a few steps closer to understanding, from a genetic sense, why sharks exhibit some characteristics that are highly desirable by humans.

Sharks and rays are known to be highly efficient wound healers, and it is suspected they show a greater resistance to cancerous malignancies. These properties are likely tied to the functioning of their immune systems, fine-tuned over 400 million years of evolution.

A study published Jan. 30 in thejournal BMC Genomics provides the first evidence that some shark and ray immunity genes have undergone evolutionary adaptation that may be tied to these novel immune system abilities.

The study was co-led by Michael Stanhope, Cornell professor of population medicine and diagnostic sciences, and Mahmood Shivji, director of the Save Our Seas Shark Research Center and the Guy Harvey Research Institute at Nova Southeastern University. Nicholas Marra, a postdoctoral associate in Stanhope’s lab, is the paper’s first author.

Two shark immune genes, legumain and Bag1,stand out.Both of these genes have counterparts in humans, where their overexpression is known to be associated with a range of cancers. The new research shows that these genes in sharks, however, have become modified through evolutionary natural selection.

“The signal of selection in these specific shark immunity genes is especially intriguing in the context that they are involved in promoting cancer in humans, while at the same time sharks are suspected to have higher resistance to cancers,” said Shivji.

The Bag1gene, for example, codes for a protein that in humans is involved in inhibiting an essential natural process known as apoptosis, or programmed cell death. This is important because the programmed cell-death process works to eliminate dysfunctional cells, and one of the hallmarks of cancer is the ability of malignant cells to evade this process. The shark-specific signature of adaptation found in the Bag1 gene may indicate an alternative or modified role for this gene that could alter its tendency to inhibit programmed cell death in sharks.

In addition, shark DNA sequences provide clues that may explain their rapid wound healing abilities despite being immersed in seawater, whose bacteria could be expected to cause infection in open wounds. The research team found that compared with bony fishes, the four species of sharks and ray examined not only had a much higher proportion of genes involved in antibody-mediated immunity, but also that several of the infection immunity-related genes were expressed only in the sharks and rays.

“This higher proportion of genes involved in adaptive [antibody] immunity function could be a key reason behind the infection-fighting and fast wound-healing abilities of sharks and rays,” Stanhope said. “Previous studies of the shark immune system have already yielded some surprises in terms of antibody structure, and these new genetic findings further add to the box of biological novelties in this highly successful vertebrate lineage.”

http://www.news.cornell.edu/stories/2017/01/sharks-show-novel-evolution-immune-cancer-related-genes

Rate

1

View Rating Log

Reply

Use magic Report


ADVERTISEMENT


Post time 3-2-2017 09:32 AM From the mobile phone | Show all posts
Good sharing tq
Reply

Use magic Report

You have to log in before you can reply Login | Register

Points Rules

 

Category: Kesihatan


ADVERTISEMENT



 

ADVERTISEMENT


 


ADVERTISEMENT
Follow Us

ADVERTISEMENT


Mobile|Archiver|Mobile*default|About Us|CariDotMy

1-11-2024 07:17 AM GMT+8 , Processed in 0.044613 second(s), 19 queries , Gzip On, Redis On.

Powered by Discuz! X3.4

Copyright © 2001-2021, Tencent Cloud.

Quick Reply To Top Return to the list