Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and BeyondBibi R. Yasin,1 Hassan A. N. El-Fawal,2 and Shaker A. Mousa1,*
Antonio Segura-Carretero, Academic Editor and Ana Maria Gómez Caravaca, Academic Editor
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AbstractThis review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy.Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and in vivo. This allows the fruit to prevent depletion of intrinsic protection from oxidative cell damage and assist these defense systems in reducing cell damage. Macroscopically, this mechanism may be relevant to the prevention of various adverse drug events common to chemotherapy including hepatotoxicity, nephrotoxicity, gastrotoxicity, and peripheral neuropathy. While such effects have only been studied in small animal systems, research suggests a potential application to more complex mammalian systems and perhaps a solution to some problems of chemotherapy in hepato-compromised and nephro-compromised patients.
Keywords: chemotherapy-induced adverse events, hepatotoxicity, mucositis, nephrotoxicity, peripheral neuropathy
Journal :
Int J Mol Sci. 2015 Dec; 16(12): 30075–30090.
Published online 2015 Dec 17. doi:10.3390/ijms161226210
nternational Journal of Molecular Sciences— Open Access JournalInternational Journal of Molecular Sciences (ISSN 1422-0067; CODEN: IJMCFK; ISSN 1661-6596 for printed edition) is an open access journal providing an advanced forum for chemistry, molecular physics and molecular biology, and is published monthly online by MDPI.
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AbstractThis review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy.Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and in vivo. This allows the fruit to prevent depletion of intrinsic protection from oxidative cell damage and assist these defense systems in reducing cell damage. Macroscopically, this mechanism may be relevant to the prevention of various adverse drug events common to chemotherapy including hepatotoxicity, nephrotoxicity, gastrotoxicity, and peripheral neuropathy. While such effects have only been studied in small animal systems, research suggests a potential application to more complex mammalian systems and perhaps a solution to some problems of chemotherapy in hepato-compromised and nephro-compromised patients.
Keywords:
sam1528 replied at 11-8-2016 01:13 AM
You mean terencat akal macam sorang mat slow tu yg mati2 klaim ajwa dates = paraquat?
Ha ha ... ...
bila aku klaim? cuba ko buktikan kebebalan ko itu:drool3:
Lobai_Atheist replied at 27-8-2016 04:47 AM
bila aku klaim? cuba ko buktikan kebebalan ko itu
Kan aku dah kata baca balik pos terawal aku.
Buat apa ko tanya soalan yg telah dijawab? Ini bukti yg ko ni kurang cerdik
sam1528 replied at 27-8-2016 02:03 AM
Kan aku dah kata baca balik pos terawal aku.
Buat apa ko tanya soalan yg telah dijawab? Ini buk ...
kenapa geng lobai & lobainita ko tak kata aku klaim ajwa dates sbg paraquat?:drool3:
adakah sbb mereka enggan terpalit kebebalan ko?;P
Lobai_Atheist replied at 27-8-2016 01:16 PM
kenapa geng lobai & lobainita ko tak kata aku klaim ajwa dates sbg paraquat?
adakah s ...
Ha ha , hang tanya pasal org lain kat aku pasal apa?
Pada aku , ko mati2 klaim ajwa dates = paraquat.
Ko rujuk balik aje pada post awal aku. LOL , baru skg nak tanya? Ko ni slow betul .... betul2 mat slow
sam1528 replied at 27-8-2016 09:59 AM
Ha ha , hang tanya pasal org lain kat aku pasal apa?
Pada aku , ko mati2 klaim ajwa dates = par ...
mmg pd ko yg bebal nie kurma ajwa = paraquat.......:D
tu laa........ bodo piang.......:(
minta tuhan khayalan ko kurnia akal pd ko laa.... :(
Lobai_Atheist replied at 28-8-2016 12:52 AM
mmg pd ko yg bebal nie kurma ajwa = paraquat.......
tu laa........ bodo piang.......
Ha ha .... aku rasa yg bebal adalah sorang mat slow tu yg mati2 klaim ajwa dates = paraquat
Macamana mat slow?
sam1528 replied at 28-8-2016 02:07 AM
Ha ha .... aku rasa yg bebal adalah sorang mat slow tu yg mati2 klaim ajwa dates = paraquat
Mac ...
betul laa......... ko laa mat slow yg dimaksudkan :$
Lebih kurang macam hadis habbatus sauda jugak le.. ujung2 keling2 jadi penyakit sejuk dan penyakit panas :lol:
Lobai_Atheist replied at 28-8-2016 12:11 PM
betul laa......... ko laa mat slow yg dimaksudkan
Ha ha .... mat slow kat board KKK ni satu aje
Hint : mat slow yg mati2 klaim ajwa dates = paraquat
Sapa agak2 nya
Lobai_Atheist replied at 28-8-2016 12:11 PM
betul laa......... ko laa mat slow yg dimaksudkan
cong, takyah layan janda tak laku tu cong
dari awal lagi pembaca lain dah paham maksud ko
Sis, nak test? Teguk laa paraquatparaquat tu adalah sejenis racun.. tapi si janda ni keling2 ko punya statement, dia putar belitkan komen ko kunun2 ko samakan paraquat dengan ajwa date..
biasa la cong, janda.. ko paham la kenapa laki dia lari
kemaruk replied at 28-8-2016 03:57 PM
cong, takyah layan janda tak laku tu cong
dari awal lagi pembaca lain dah paham maksud ko
Ha ha , the loser in kamaruk dah muncul balik
Nak start bohong lagi dgn video MEMRI tu ke? Kan ko dah kena teruk ..... nak lagi ke?
LOL .... kesian .... tak puas hati nampak nya
You have come to the aid of your boyfriend who is in trouble ..... awwww cute isn't it ....
alamak
janda keling quote bangkem
baik bangkem lari cepat sebelum dia keling2 komen bangkem
keling-keling macam tenggiling
kemaruk replied at 28-8-2016 07:57 AM
cong, takyah layan janda tak laku tu cong
dari awal lagi pembaca lain dah paham maksud ko
Janda kaa?:o
Ingatkan laki pervert;P
Lobai_Atheist replied at 28-8-2016 05:00 PM
Janda kaa?
Ha ha ..... baguys lah korang dua orang
Temberang sama sendiri lepas tu gelak paksa
Sorang mat slow .... sorang lagi kaki temberang .... LOL
Lobai_Atheist replied at 28-8-2016 05:00 PM
Janda kaa?
janda keling
ko tengok la camne dia putarbelitkan komen ko, cong
ini la perangai lobainita tak reti malu takde maruah melacurkan diri semata-mata nak jadi juara dalam forum ;P
dia tak perasan kot, satu forum boleh baca kekelingan dalam tulisan dia :lol:
kemaruk replied at 28-8-2016 09:47 AM
janda keling
ko tengok la camne dia putarbelitkan komen ko, cong
Tak kisah nak auta camne..... Tu mmg perangai manusia delusional.... Aku dah jumpa byk bahalol cam dia...;P
Lobai_Atheist replied at 28-8-2016 05:51 PM
Tak kisah nak auta camne..... Tu mmg perangai manusia delusional.... Aku dah jumpa byk bahalol cam ...
ujung2 senyap dah janda tu cong
takde dah spam pasal ajwa dates = paraquat
dah malu akan kekantoian lettew
kaki putar belit, tak tahu malu, takde maruah :lol:
bangkem bolayan je orang macam ni
takde kualiti.. tak setaraf dengan ilmu bangkem
Lobai_Atheist replied at 28-8-2016 05:51 PM
Tak kisah nak auta camne..... Tu mmg perangai manusia delusional.... Aku dah jumpa byk bahalol cam ...
Kesian .... sorang si mamat kemaruk kaki temberang ... sorang lagi si mat slow
Crying on each other shoulders as both got buttkicked by a big bad muslim
sam1528 replied at 28-8-2016 09:56 AM
Kesian .... sorang si mamat kemaruk kaki temberang ... sorang lagi si mat slow
Crying on each o ...
Ko dah kick the bucket?:o